INCREASED OXPHOS ACTIVITY PRECEDES RISE IN GLYCOLYTIC RATE IN H-RASV12/E1A TRANSFORMED FIBROBLASTS THAT DEVELOP A WARBURG PHENOTYPE

Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype

Abstract Background The Warburg phenotype in cancer cells has been long recognized, but there is still limited insight in the consecutive metabolic alterations that characterize its establishment.We Diecast Truck obtained better understanding of the coupling between metabolism and malignant transformation by studying mouse embryonic fibroblast-deri

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The Base Excision Repair system of Salmonella enterica serovar typhimurium counteracts DNA damage by host nitric oxide.

Intracellular Machines pathogens must withstand nitric oxide (NO.) generated by host phagocytes.Salmonella enterica serovar Typhimurium interferes with intracellular trafficking of inducible nitric oxide synthase (iNOS) and possesses multiple systems to detoxify NO.Consequently, the level of NO.stress encountered by S.Typhimurium during infection i

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